Distribution of RET Mutations and Evaluation of Treatment Approaches in Hereditary Medullary Thyroid Carcinoma in Turkey

Aydogan, Berna; Yuksel, Bagdagul; Tuna, Mazhar; Basaran, Mehtap; Kocaeli, Aysen; Ertorer, Melek; Aydin, Kadriye; GÜLDİKEN, SİBEL; Simsek, Yasin; ÖZDAMAR KARACA, ZÜLEYHA; Yilmaz, Merve; Akturk, Mujde; Anaforoglu, Inan; Kebapci, Nur; Duran, Cevdet; Taslipinar, Abdullah; KULAKSIZOĞLU, MUSTAFA; Gursoy, Alptekin; DAĞDELEN, SELÇUK; ERDOĞAN, MURAT

doi:10.4274/jcrpe.2219

Distribution of RET Mutations and Evaluation of Treatment Approaches in Hereditary Medullary Thyroid Carcinoma in Turkey

Aydogan B. I., Yuksel B., Tuna M. M., Basaran M. N., Kocaeli A. A., Ertorer M. E., ...Daha Fazla

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, cilt.8, sa.1, ss.13-20, 2016 (SCI-Expanded, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 8 Sayı: 1
Basım Tarihi: 2016
Doi Numarası: 10.4274/jcrpe.2219
Dergi Adı: JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.13-20
Anahtar Kelimeler: Sporadic medullary thyroid carcinoma, hereditary medullary thyroid carcinoma, multiple endocrine neoplasia, RET mutation, ENDOCRINE NEOPLASIA TYPE-2, PROTOONCOGENE MUTATIONS, MEN 2A, PREVALENCE, FAMILIES, CANCER, GUIDELINES, MANAGEMENT, EXPERIENCE, PHENOTYPE
Ankara Üniversitesi Adresli: Evet

Özet

Objective: This retrospective multicenter study, centrally conducted and supported by the Society of Endocrinology and Metabolism of Turkey, aimed to evaluate the impact of free RET proto-oncogene testing in medullary thyroid carcinoma (MTC) patients. Surgical timing, adequacy of the treatment, and frequency of prophylactic thyroidectomy (PTx) in mutation carriers were also assessed.