Genotoxic effects of mycotoxins

Ulger T. G., Uçar A., Çakıroğlu F. P., Yılmaz S.

TOXICON, vol.185, pp.104-113, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 185
  • Publication Date: 2020
  • Doi Number: 10.1016/j.toxicon.2020.07.004
  • Journal Name: TOXICON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, EMBASE, Environment Index, MEDLINE, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Page Numbers: pp.104-113
  • Keywords: Mycotoxin, Aflatoxins, Ochratoxin A, Patulin, Fumonisins, Zearalenone, Trichothecene, Ergot alkaloids, Genotoxicity, Health effect, INDUCED OXIDATIVE STRESS, IN-VITRO GENOTOXICITY, RENAL TUMOR-FORMATION, FUMONISIN B-1, OCHRATOXIN-A, AFLATOXIN B-1, DNA-DAMAGE, CHROMOSOME-ABERRATIONS, HEPATOCELLULAR-CARCINOMA, FUSARIUM MYCOTOXINS
  • Ankara University Affiliated: Yes

Abstract

Fungi produce mycotoxins in the presence of appropriate temperature, humidity, sufficient nutrients and if the density of the mushroom mass is favorable. Although all mycotoxins are of fungal origin, all toxic compounds produced by fungi are not called mycotoxins. The interest in mycotoxins first started in the 1960s, and today the interest in mycotoxin-induced diseases has increased. To date, 400 mycotoxins have been identified and the most important species producing mycotoxins belongs to Aspergillus, Penicillium, Alternaria and Fusarium genera. Mycotoxins are classified as hepatotoxins, nephmtoxins, neurotoxins, immunotoxins etc. In this review genotoxic and also other health effects of some major mycotoxin groups like Aflatoxins, Ochratoxins, Patulin, Fumonisins, Zearalenone, Trichothecenes and Ergot alkaloids were deeply analyzed.