Synthesis of 3-substituted phenacyl-5-[2-phenyl-4H-4-oxo-1-benzopyran-6-yl)methylenyl]-thiazolidine-2,4-diones and evaluation of their antimicrobial activity

KILCIGİL G., Altanlar N.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, cilt.50, sa.2, ss.154-157, 2000 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 2
  • Basım Tarihi: 2000
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Index Chemicus (IC)
  • Sayfa Sayıları: ss.154-157
  • Anahtar Kelimeler: flavonyl-thiazolidinediones, phenacyl-thiazolidine-2,4-diones, antifungal and, antimicrobial activity, 3-substituted, synthesis, SUBSTITUTED THIAZOLIDINEDIONES
  • Ankara Üniversitesi Adresli: Evet

Özet

Synthesis and physico-chemical properties of two 3-substituted phenacyl-thiazolidine-2,4-diones (2c-d) and four 3-substituted phenacyl-5-[2-phenyl-4H-4-oxo-1-benzopyran-6-yl)methyl-enyl]-thiazolidine-2,4-diones (4a-d) are described. These products were synthesized by Knoevenagel reaction from flavone-6-carboxaldehyde (3) and 3-(substituted phenacyl)-thiazolidine-2,4-diones (2a-d). Antibacterial and antifungal activities were investigated for these compounds.