The effects of acute and intermittent hypoxia on the expressions of HIF-1 alpha and VEGF in the left and right ventricles of the rabbit heart

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Tekin D., Dursun A. D., BAŞTUĞ M., Karaorman G., FIÇICILAR H.

ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.11, sa.5, ss.379-385, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 5
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5152/akd.2011.104
  • Dergi Adı: ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.379-385
  • Anahtar Kelimeler: Acute hypoxia, intermittent hypoxia, expression, heart, HIF-1 alpha, rabbit, VEGF, ventricle, MESSENGER-RNA EXPRESSION, HUMAN SKELETAL-MUSCLE, RAT-HEART, INDUCIBLE FACTOR-1, HYPOBARIC HYPOXIA, ISCHEMIA, PROTEIN, ANGIOGENESIS, PERFORMANCE, ADAPTATION
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: Hypoxia-inducible factor-1 alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF) are involved in signaling mechanisms of cellular responses to hypoxia. These factors have been investigated in tissue samples by simulating different altitudes by changing the percentage of oxygen. We aimed first to evaluate the effect of normobaric, systemic hypoxia (11% O(2)) on HIF-1 alpha and VEGF mRNA levels in the heart muscle; secondly, to compare the levels of HIF-1 alpha and VEGF mRNA in the left and right ventricle muscles.