Akademik Veri Yönetim Sistemi
European Biophysics Journal, 2026 (SCI-Expanded, Scopus)
The quality of life of millions of people worldwide is reduced due to eye defects. A predictable perspective is needed to express ophthalmology and drug development studies using functional and simpler models and systems to explain complex mechanisms, such as the eye. Organ-on-a-chip (OoC) technology is used to develop models under in vitro conditions, according to the needs of specific tissue or organ studies. Cellular functions of cells in a three-dimensional (3D) cell culture environment are expected to be more efficient than those of monolayer cells in a two-dimensional (2D) culture. This situation is similar to that of planned studies on eye tissues. Efficient results in terms of cell-cell interactions were obtained in eye-on-chip studies, where 3D cell culture was created with a perfusion system in microfluidic chip channels created using materials such as polymethylmethacrylate (PMMA) and polydimethylsiloxane (PDMS). Recently, eye-chip technology has been used to mimic eye tissues and reduced the economic burden of pharmacological studies. Eye-chip studies designed for cornea, choroid, retina, tear film, and eye disease models using retinal organoids, cell lines, and stem cells yielded fruitful results in the literature. Lower-cost and environmentally friendly ocular tissue models are required for toxicity tests of pharmacological drugs used as a treatment method. In this review, studies on the microfluidics-organized eye-chip technology are reviewed. It is important to conduct studies on the mechanisms of eye disease and eye drop development. Therefore, studies on this new technology developed by the combined use of eye diseases, biophysics, and microfluidics are discussed.