Autologous platelet collection and storage to support thrombocytopenia in a leukemia patient with platelet alloimmunization undergoing chemotherapy
Turkish Journal of Haematology, vol.20, no.4, pp.233-236, 2003 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 20 Issue: 4
- Publication Date: 2003
- Journal Name: Turkish Journal of Haematology
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.233-236
- Keywords: Allogeneic, Blood transfusion autologous, Immunization, Platelet, Transfusion
- Ankara University Affiliated: Yes
Abstract
Platelet alloimmunization occurs frequently in multitransfused patients. To prevent the posttransfusion complications donor white blood cells (WBCs) must be removed from the platelet concentrates (PC). But sometimes the centrifugation and filtration of WBC is not enough and in such conditions HLA-matched PC are recommended. Cryopreservation of autologous PC offers a potential solution to this problem. We investigated the feasibility of supporting the aplastic period after chemotherapy in a 54-year-old leukemia patient with autologous platelets collected by apheresis and cryopreserved. Our case report demonstrates that autologous apheresis platelet transfusion might be a feasible approach to high risk patients with bleeding tendencies.