Endocytosis of light chains induces cytokines through activation of NF-kappa B in human proximal tubule cells

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Sengul Ş., Zwizinski C., Simon E., Kapasi A., Singhal P., Batuman V.

KIDNEY INTERNATIONAL, vol.62, no.6, pp.1977-1988, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 6
  • Publication Date: 2002
  • Doi Number: 10.1046/j.1523-1755.2002.00660.x
  • Journal Name: KIDNEY INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1977-1988
  • Keywords: interleukin-6, monocyte chemoattractant protein-1, proteinuria, progressive kidney disease, human serum albumin, myeloma, BRUSH-BORDER MEMBRANES, INTERLEUKIN-6 TRANSGENIC MICE, BENCE-JONES PROTEINS, MULTIPLE-MYELOMA, EPITHELIAL-CELLS, PROGRESSIVE NEPHROPATHIES, INTERSTITIAL INFLAMMATION, URINARY-EXCRETION, GENE-EXPRESSION, BINDING-SITES
  • Ankara University Affiliated: Yes

Abstract

Background. In proteinuric states increased cytokine production through endocytosis of filtered proteins by proximal tubule cells (PTCs) has been proposed as a major mechanism mediating tubulointerstitial injury and progressive kidney disease. We studied the effects of six different light chains (LCs) on the production of cytokines in cultured human PTCs.