Recent Studies and Biological Aspects of Substantial Indole Derivatives with Anti-cancer Activity

SÜZEN S.

CURRENT ORGANIC CHEMISTRY, cilt.21, sa.20, ss.2068-2076, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 21 Sayı: 20
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2174/1385272821666170809143233
  • Dergi Adı: CURRENT ORGANIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2068-2076
  • Anahtar Kelimeler: Antioxidant, anticancer, carcinogenesis, DNA mutation, drug development, oxidative stress, PANCREATIC-CANCER CELLS, DBM IMPROVED SURVIVAL, BREAST-CANCER, CYCLE ARREST, 3,3'-DIINDOLYLMETHANE DIM, OBJECTIVE RESPONSE, PERFORMANCE STATUS, OXIDATIVE STRESS, DOWN-REGULATION, IN-VITRO
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: All cancers are leading causes of morbidity and mortality worldwide. The urgent need for new lead compounds for the treatment of cancer is higher than ever before. Scientists search and try to discover effective but less harmful new anti-tumor agents. Surgery, chemotherapy and radiation are the best-known methods for treating cancer, however, they continued to be limited. Rising efforts of the scientists toward success of the drug discovery is increasing. Indole ring is considered as a key molecule existing in various biologically active compounds. Indole derivatives are recognized to prevent proliferation and invasion of many cancer cells.