Voltammetric behavior of telmisartan and cathodic adsorptive stripping voltammetric method for its assay in pharmaceutical dosage forms and biological fluids
Electroanalysis, cilt.22, sa.17-18, ss.2101-2109, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 17-18
- Basım Tarihi: 2010
- Doi Numarası: 10.1002/elan.201000100
- Dergi Adı: Electroanalysis
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2101-2109
- Anahtar Kelimeler: Hanging mercury drop electrode, Pharmaceuticals, Spiked human serum, Square-wave cathodic adsorptive stripping voltammetry, Telmisartan
- Ankara Üniversitesi Adresli: Evet
Özet
Electrochemical behavior of Telmisartan and optimum conditions for its assay were investigated by using cyclic voltammetry and square-wave voltammetry. All studies were based on the quasi-reversible and adsorption-controlled electrochemical reduction signal of TS at about -1.50 V versus Ag/AgCl at pH 10.0 in Britton-Robinson buffer. The peak current was found to change linearly with concentration from 1.69 nM (0.87 μg/L) to 27.5 nM (14.15 μg/ L). The limit of detection and the limit of quantification were found to be 1.05 nM (0.54 μg/L) and 3.49 nM (1.79 μg/L), respectively. The method was successfully applied to different samples with good recoveries at about 100%. © 2010 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim.