Voltammetric behavior of telmisartan and cathodic adsorptive stripping voltammetric method for its assay in pharmaceutical dosage forms and biological fluids

Taşdemir I. H., AKAY M. A., ERK N., Kiliç E.

Electroanalysis, cilt.22, sa.17-18, ss.2101-2109, 2010 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 17-18
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1002/elan.201000100
  • Dergi Adı: Electroanalysis
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2101-2109
  • Anahtar Kelimeler: Hanging mercury drop electrode, Pharmaceuticals, Spiked human serum, Square-wave cathodic adsorptive stripping voltammetry, Telmisartan
  • Ankara Üniversitesi Adresli: Evet

Özet

Electrochemical behavior of Telmisartan and optimum conditions for its assay were investigated by using cyclic voltammetry and square-wave voltammetry. All studies were based on the quasi-reversible and adsorption-controlled electrochemical reduction signal of TS at about -1.50 V versus Ag/AgCl at pH 10.0 in Britton-Robinson buffer. The peak current was found to change linearly with concentration from 1.69 nM (0.87 μg/L) to 27.5 nM (14.15 μg/ L). The limit of detection and the limit of quantification were found to be 1.05 nM (0.54 μg/L) and 3.49 nM (1.79 μg/L), respectively. The method was successfully applied to different samples with good recoveries at about 100%. © 2010 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim.