Superoxide dismutase, catalase, glutathione peroxidase and xanthine oxidase in diabetic rat lenses

Cekic O., Bardak Y., Totan Y., Akyol O., Zilelioglu G.

OPHTHALMIC RESEARCH, vol.31, no.5, pp.346-350, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 5
  • Publication Date: 1999
  • Doi Number: 10.1159/000055557
  • Journal Name: OPHTHALMIC RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.346-350
  • Keywords: diabetic rat lenses, superoxide dismutase, catalase, glutathione peroxidase, xanthine oxidase, MODELING CORTICAL CATARACTOGENESIS, ANTIOXIDANT THERAPY, LIPID-PEROXIDATION, GLUCOSE, PROTECTION, MECHANISM, GLAUCOMA, INVITRO, EYE
  • Ankara University Affiliated: No

Abstract

The activities of the protective enzymes, superoxide dismutase, catalase, glutathione peroxidase and of xanthine oxidase, an enzyme acting as a source of O-2(-), were measured in the lenses of alloxan-induced diabetic and control rats, Superoxide dismutase and glutathione peroxidase activities were found to be significantly decreased, while catalase and xanthine oxidase activities were increased. This means that the ratio of the oxidant/antioxidant enzymes increases in the diabetic rat lens, suggesting an increased oxidative stress. This imbalance is possibly an important contributing factor in the pathogenesis of diabetic cataract.