Toxic concentrations of selenite shortens repolarization phase of action potential in rat papillary muscle

Ugur M., Ayaz M., ÖZDEMİR S., Turan B.

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.89, sa.3, ss.227-238, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 89 Sayı: 3
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1385/bter:89:3:227
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.227-238
  • Anahtar Kelimeler: action potential, sodium current, papillary muscle, repolarization, sodium selenite, myocardium, myocyte, HYDROGEN-PEROXIDE, SODIUM SELENITE, ARRHYTHMIAS, SYSTEMS, TISSUE, OXYGEN
  • Ankara Üniversitesi Adresli: Evet

Özet

Selenium (Se) has long been recognized as both an essential mammalian nutrient and a hazardous element. Sodium selenite is commonly used as a dietary supplement for the treatment of Se deficiency. On the other hand, chronic Se toxicity has been demonstrated to affect the major organs, including the heart, in experimental animals.