Prognostic usefulness of some parameters in dogs with canine parvovirus

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Baştan İ., Kurtdede A., Özen D.

ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI, cilt.60, sa.1, ss.53-58, 2013 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1501/vetfak_0000002553
  • Dergi Adı: ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.53-58
  • Anahtar Kelimeler: Canine parvovirus, cTn-I, prognosis, TNF-alpha, CARDIAC TROPONIN-I, ENTERITIS, DIAGNOSIS, DISEASE, SUSCEPTIBILITY, MYOCARDITIS, INFECTION, SEPSIS
  • Ankara Üniversitesi Adresli: Evet

Özet

The purpose of this study was to evaluate the prognostic usefulness of some parameters in dogs with canine parvovirus (CPV). Fifty-nine animals which consist of 39 ill and 20 healthy puppies were used in the study. All puppies were underwent a complete physical examination and laboratory variables (CBC, serum routine biochemistry profile, cTn-I, TNF-alpha) on their first admission to clinic and on following every day before treatment until discharge or death. Despite aggressive treatment with available therapy, 14 of 39 dogs died. Non-survivor dogs had significantly lower leukocyte, lymphocyte, monocyte and granulocyte counts but had significantly higher serum urea and creatinine concentrations than those of survivor dogs at presentation (p<0.05). Serum cTn-I concentration level were positive in 11 of 14 non-survival dogs and negative in all of the survival dogs. The relative risk of death for the dogs with TNF-alpha positive was 3,39 times (95% CI:1,53-7,52) higher than that of dogs with TNF-alpha negative. This study demonstrates that leukocyte, lymphocyte, granulocyte, monocyte counts, serum urea and creatinine concentrations, cTn-I and TNF-alpha levels are useful parameters for predicting the prognosis of dogs with CPV.