Preparation of polymeric microspheres by the solvent evaporation method using sucrose stearate as a droplet stabilizer

YÜKSEL N., Baykara T.

JOURNAL OF MICROENCAPSULATION, vol.14, no.6, pp.725-733, 1997 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 6
  • Publication Date: 1997
  • Doi Number: 10.3109/02652049709006822
  • Journal Name: JOURNAL OF MICROENCAPSULATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.725-733
  • Keywords: polymeric microspheres, nicardipine hydrochloride, solvent evaporation, droplet stabilizer, sucrose stearate, MICROCAPSULE PROPERTIES, DIFFUSION METHOD, FORMULATION, KETOPROFEN, RELEASE, ACID
  • Ankara University Affiliated: Yes

Abstract

Polymeric microspheres containing nicardipine hydrochloride (HCl) as a reference drug were prepared with the acrylic polymers Eudragit RS and L by the solvent evaporation method. Different concentrations of sucrose stearate as a droplet stabilizer were used. Sucrose stearate affected the diffusion rate of the solvent from the preliminary emulsion droplets to the outer phase for the formation of microspheres. Increasing concentrations of sucrose stearate in the formulations caused increasing porosity on the surface of the microspheres. However, a correlation between the concentrations of sucrose stearate and diameters of microspheres could not be assessed. From this point of view, during processing, applied stirring rate was important.