Akademik Veri Yönetim Sistemi
Turkish Journal of Gastroenterology, cilt.14, sa.2, ss.102-105, 2003 (SCI-Expanded)
Background/aims: The aim of this study was to clarify whether folinic acid has any choleretic effect in humans, as observed by Kajiyama et al. in both clinical and experimental studies. Methods: The choleretic effect of folinic acid was analyzed prospectively in a subgroup of patients who had external biliary catheters with periampullary tumors causing complete biliary obstruction. Folinic acid (50mg/day) was administered twice with a 24-hour interval between each dose. Daily bile volume was then recorded on the three consecutive days following the first dose of folinic acid. Mean bile flows (basal output=mean bile volume of four days) before and after (fifth, sixth and seventh days) the initiation of folinic acid administration were then compared. Results: Mean bile volumes were determined as baseline output: 669.20±235.18, 5th day=: 668.63±235.26, sixth day: 670.45±235.08, and seventh day: 670.00±235.11. No significant difference in daily bile volumes before and after folinic acid administration was detected (p>0.05). Conclusion: No choleretic effect of intravenous folinic acid administration was observed in this prospective clinical study. This finding was contrary to our previous study on this subject.