EFFECTS OF CALCIUM-CHANNEL BLOCKERS ON FORMALIN-INDUCED NOCICEPTION AND INFLAMMATION IN RATS

GÜRDAL H., SARA Y., TULUNAY F.

PHARMACOLOGY, cilt.44, sa.5, ss.290-296, 1992 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 5
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1159/000138932
  • Dergi Adı: PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.290-296
  • Anahtar Kelimeler: NOCICEPTION, INFLAMMATION, FORMALIN TEST, RAT PAW, CALCIUM CHANNEL BLOCKERS, DIVALENT-CATIONS, IONOPHORE, MORPHINE, MICE, ANALGESIA, CHELATORS, PAIN
  • Ankara Üniversitesi Adresli: Evet

Özet

The possible anti-inflammatory and antinociceptive effects of nitrendipine, nicardipine, diltiazem and verapamil were examined with formalin test in the rat paw. Pretreatment with these calcium channel blockers 1 h before formalin injection diminished formalin-induced inflammatory changes and nociceptive responses. Formalin-induced nociceptive responses were inhibited 20-90% by the calcium channel blockers. Nitrendipine and nicardipine were found to be highly effective in inhibiting the inflammatory changes, whereas the effects of verapamil and diltiazem were partial. Administration of naloxone affected neither the inflammatory changes and nociceptive responses induced by formalin nor the anti-inflammatory and antinociceptive effects of the calcium channel blockers. The results suggest the possible anti-inflammatory and naloxone-insensitive antinociceptive properties of calcium channel blockers.