Antitumor activities on HL-60 human leukemia cell line, molecular docking, and quantum-chemical calculations of some sulfonamide-benzoxazoles

ÖKSÜZOĞLU E., ERTAN BOLELLİ T., CAN H., Tarhan M., ÖZTÜRK K., YILDIZ İ.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, cilt.45, sa.7, ss.1388-1396, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 7
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/21691401.2016.1241796
  • Dergi Adı: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1388-1396
  • Anahtar Kelimeler: Antitumor activity, benzoxazole, sulfonamide, HL-60 human leukemia cell line, molecular docking, quantum chemical calculations, topoisomerase II, TOPOISOMERASE-II INHIBITORS, IN-VITRO, BIOLOGICAL EVALUATION, HETEROCYCLIC-COMPOUNDS, ANTIMICROBIAL AGENTS, ANTICANCER ACTIVITY, DERIVATIVES, CANCER, BENZIMIDAZOLE, RESISTANCE
  • Ankara Üniversitesi Adresli: Evet

Özet

We previously synthesized some novel benzoxazole derivatives-containing sulfonamide. In this study, the compounds were investigated for their antitumor activities against the HL-60 human leukemia cells, using the MTT assay. Moreover, quantum chemical calculations using the DFT methods were applied for understanding the difference in antitumor activity. Additionally, molecular docking into active site of the DNA Topo II enzyme was performed on 3QX3. PDB file in order to find out possible mechanism of antitumor effect.