P53, bcl-2 and bax immunoreactivity as predictors of response and outcome after chemotherapy for metastatic germ cell testicular tumours.

Baltaci S., Orhan D., Turkolmez K., Yesilli C., Beduk Y., Tulunay O.

BJU international, cilt.87, sa.7, ss.661-6, 2001 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 87 Sayı: 7
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1046/j.1464-410x.2001.02151.x
  • Dergi Adı: BJU international
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.661-6
  • Anahtar Kelimeler: p53, bcl-2, bax, testis cancer, chemoresistance, TESTIS CANCER, TUMORS, GENE, APOPTOSIS, MUTATIONS, DEATH, RISK, EXPRESSION, ETOPOSIDE, CLONING
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective To evaluate the roles of p53, bcl-2 and bax as determinants of chemosensitivity in testicular cancers and to assess whether immunohistochemical expression of these proteins in testicular germ cell tumours (GCTs) could be used to predict the outcome in patients with metastatic testicular GCTs.