Investigation of HER-2 codon 655 single nucleotide polymorphism frequency and c-ErbB-2 protein expression alterations in gastric cancer patients

TUFAN N. L., Bir F., Calli-Demirkan N.

WORLD JOURNAL OF GASTROENTEROLOGY, vol.12, no.20, pp.3283-3287, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 20
  • Publication Date: 2006
  • Doi Number: 10.3748/wjg.v12.i20.3283
  • Journal Name: WORLD JOURNAL OF GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3283-3287
  • Keywords: gastric carcinoma, HER-2, c-erbB-2, single nucleotide polymorphism, immunohistochemistry, GROWTH-FACTOR RECEPTOR, BREAST-CANCER, GENE AMPLIFICATION, OVARIAN-CANCER, NEU ONCOGENE, C-MET, RISK, OVEREXPRESSION, CARCINOMAS, ERBB2
  • Ankara University Affiliated: No

Abstract

AIM: To investigate both whether the risk of gastric cancer is associated with the Ile/Val single nucleotide polymorphism (SNP) of human epidermal growth factor receptor-2 (HER-2) transmembrane domain-coding region at codon 655 and the suggested existence of HER-2 expression in gastric cancer cases in a Turkish patient group.