Investigation of HER-2 codon 655 single nucleotide polymorphism frequency and c-ErbB-2 protein expression alterations in gastric cancer patients

TUFAN N. L., Bir F., Calli-Demirkan N.

WORLD JOURNAL OF GASTROENTEROLOGY, cilt.12, sa.20, ss.3283-3287, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 20
  • Basım Tarihi: 2006
  • Doi Numarası: 10.3748/wjg.v12.i20.3283
  • Dergi Adı: WORLD JOURNAL OF GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3283-3287
  • Anahtar Kelimeler: gastric carcinoma, HER-2, c-erbB-2, single nucleotide polymorphism, immunohistochemistry, GROWTH-FACTOR RECEPTOR, BREAST-CANCER, GENE AMPLIFICATION, OVARIAN-CANCER, NEU ONCOGENE, C-MET, RISK, OVEREXPRESSION, CARCINOMAS, ERBB2
  • Ankara Üniversitesi Adresli: Hayır

Özet

AIM: To investigate both whether the risk of gastric cancer is associated with the Ile/Val single nucleotide polymorphism (SNP) of human epidermal growth factor receptor-2 (HER-2) transmembrane domain-coding region at codon 655 and the suggested existence of HER-2 expression in gastric cancer cases in a Turkish patient group.