Atıf İçin Kopyala
TIRIS G., Mehmandoust M., Lotfy H. M., ERK N., Joo S., Dragoi E., ...Daha Fazla
CHEMOSPHERE, cilt.303, 2022 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
303
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Basım Tarihi:
2022
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Doi Numarası:
10.1016/j.chemosphere.2022.135074
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Dergi Adı:
CHEMOSPHERE
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), Artic & Antarctic Regions, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Environment Index, Food Science & Technology Abstracts, Geobase, Greenfile, MEDLINE, Metadex, Pollution Abstracts, Public Affairs Index, Veterinary Science Database, Civil Engineering Abstracts
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Anahtar Kelimeler:
Antihypertensive drugs, Amlodipine, Telmisartan, Hydrochlorothiazide, HPLC, Spectrophotometry, 10 ANTIHYPERTENSIVE DRUGS, UHPLC-MS/MS METHOD, HUMAN PLASMA, LIQUID-CHROMATOGRAPHY, DOSAGE FORM, VALIDATION, QUANTIFICATION, BESYLATE, BULK, MIXTURE
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Ankara Üniversitesi Adresli:
Evet
Özet
For the quantifiable amounts of Telmisartan (TLM) and Hydrochlorothiazide (HYD) in the presence of Amlodipine (AML) in a ternary mixture of synthetic laboratory mixture, a novel, sensitive, quick, and practical reversed-phase high-performance liquid chromatography (RP-HPLC) method was given. In order to separate, a Waters Spherisorb ODS-2 C18 column was used. For HYD, TLM, and AML, these techniques were viable over linearity ranges of 4-12 mu g/mL, 4-25 mu g/mL, and 5-40 mu g/mL, respectively. The mobile phase system was acetonitrile:methanol: phosphate buffer at pH 2.5 (65:5:30 v/v/v), and the flow rate was 1.5 mL/min. Novel spectrophotometric methods were applied for active substances to determine simultaneously. The first method is absorptivity centering using factorized spectrum, and the second method is dual amplitude difference coupled