Akademik Veri Yönetim Sistemi
Turk Hijyen ve Deneysel Biyoloji Dergisi, cilt.77, sa.4, ss.449-458, 2020 (Scopus)
© 2020. Turk Hij Den Biyol Derg. All rights reserved.Objective: The purpose of this study is to observe any aging and swimming exercise associated changes in the rat thoracic aorta and gastrocinemius feed artery. Methods: 4-month and 24-month old female rats were used and divided into four following groups: sedentary young, trained young, sedentary old, and trained old. Swimming exercise was performed for 8 weeks (60 min/day, 5 days/week). Thoracic Aorta and gastrocinemius feed artery isolated from the rats. Thoracic Aorta rings were mounted on organ bath and gastrocinemius feed arteries were mounted on wire myograph. Contraction responses of all vessel rings in presence and absence of HO inhibitor (CrMP) were recorded as an endogenous CO contribution to vascular tonus. The effect of exogenous CO relaxation response were assesed by CO releasing molecule (CORM). Results: Phenylephrine dose- response curves with or without CrMP were smilar in all groups both aortic rings and gastrocnemius feed artery. The maximum PE contraction responses obtained after CrMP incubation were significantly higher in the GE, YS and YE groups (p <0.05) in the aortic rings, and only significantly higher in the GS and GE groups in the gastrocnemius feed arteries (p <0,01). There was no differences in the maximum vasodilatation response of CORM reported for all groups in gastrocnemius feed artery. However, in the old groups CORM Emax values were established significantly lower than that the young groups in the aortic rings (p<0,05). Conclusion: As a results of this study; exercise and aging have no effect on CO responses in the gastrocnemius feed artery. But the CO relaxation response is decreased by aging in the thoracic aorta of elderly rats and exercise does not have an enhancing contribution for CO relaxation response in both old and young rats.