Cyclooxygenase-2 (COX-2) gene polymorphism in patients with differentiated thyroid carcinomas in the Turkish population

Ucan B., Ozbek M., ŞAHİN M., Kizilgul M., Cakal E.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.47, no.6, pp.1848-1853, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.3906/sag-1708-49
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1848-1853
  • Keywords: Cyclooxygenase-2, thyroid cancer, gene polymorphism, SQUAMOUS-CELL CARCINOMA, LUNG-CANCER, BREAST-CANCER, PROGNOSTIC-SIGNIFICANCE, COLORECTAL-CANCER, PAPILLARY CARCINOMA, POOR-PROGNOSIS, EXPRESSION, RISK, SYNTHASE
  • Ankara University Affiliated: Yes

Abstract

Background/aim: The most common thyroid malignancies are papillary and follicular thyroid carcinomas. They account for approximately 85%-90% of all thyroid cancers. Recent studies have reported the relevance of cyclooxygenase-2 (COX-2) gene polymorphism in human carcinogenesis. The aim of this study was to investigate the relationship between thyroid carcinoma and COX-2 gene polymorphism in the Turkish population.