Akademik Veri Yönetim Sistemi
Journal of Molecular Structure, cilt.1356, 2026 (SCI-Expanded, Scopus)
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases belonging to the metalloproteinase superfamily, with MMP-2 (gelatinase A) and MMP-9 (gelatinase B) being among the most studied members, due to their involvement in cancer progression. Inhibition of these gelatinases represents a promising strategy in cancer therapy. In this study, a novel series of aminoanilide-based compounds (9a-f and 12a-d), incorporating an aminoanilide moiety as the zinc-binding group, was synthesized and evaluated for their inhibitory activity against MMP-2 and MMP-9, as well as for their cytotoxic effects on A549 lung carcinoma, MCF-7 breast carcinoma, and K562 myeloid leukemia cell lines. Among the synthesized compounds, 12c and 12d showed notable MMP-2 inhibitory activity, with IC₅₀ values of 0.521 µM and 0.099 µM, respectively and exerted significant cytotoxicity in A549 cells. Further studies on these two compounds revealed that they induced cell cycle arrest at the G0/G1 phase, triggered apoptosis, reduced mitochondrial membrane potential, and increased caspase activation in A549 cells. Collectively, these findings highlight compounds 12c and particularly 12d as promising anticancer candidates warranting further mechanistic and in vivo investigations.