Association of blood melatonin and ferritin levels in children with Thalassemia major Talasemi majorlu çocuklarda plazma melatonin düzeyleri ve serum ferritin düzeyleriyle ilişkisi

Sari E., Kesik V., Karaoğlu A., Özkan E., Ince E., Gürsel O., ...Daha Fazla

Gulhane Medical Journal, cilt.58, sa.2, ss.126-128, 2016 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5455/gulhane.168044
  • Dergi Adı: Gulhane Medical Journal
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.126-128
  • Anahtar Kelimeler: Children, Ferritin, Melatonin, Thalassemia major
  • Ankara Üniversitesi Adresli: Evet

Özet

© Gülhane Askeri Tip Akademisi 2016.Context: The effects of iron load especially in patients receiving regular transfusion on pineal gland and its major neurohormone melatonin is not known. Objective: The objective of the present study was to evaluate the possible alterations on melatonin rhythm in regularly transfused children with thalassemia major. Materials and Methods: Twenty patients with thalassemia major were enrolled in this study. Results: There was no significant difference for daytime melatonin levels between control group and thalassemia major patients. However, nighttime melatonin levels were significantly lower in thalassemia major patients than control group. Conclusion: As a conclusion, Iron overload may have detrimental effects that leads to disruption in melatonin rhythm.