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Bulletin of Gulhane Military Medical Academy, vol.21, no.4, pp.589-594, 1979 (Scopus)
During the last decade, many articles have proposed that anesthetic medications might suppress cellular immunity. But some authors assert the role of surgical trauma in this inhibition. A recent study has confirmed that halothane anesthesia has suppressed Lymphocyte transformation against PHA in the culture. This study was performed in the same conditions, but the anesthetics used were morphine + Dizapam + N2O+O2. Peripheral Lymphocyte transformation in 15 patients under thyroidectomy operations due to simple goitre was performed in culture conditions with tritiated thymidine incorporation. DPM values which reflect the DNA synthesis were as follows, (per 1 x 106 lymphocytes in a culture tube): before anesthesia, 41699.7 ± 4661.3; after anesthesia, 41421.1 ± 4495.6; 24 hr after operation, 40720.2 ± 4446.9; and 168 hr after operation, 42297.0 ± 4812.8. It was observed that these agents did not significantly inhibit lymphocyte transformation in the technique of 3H-Thymidine uptake. In any case which is not to be desired, it was concluded that suppression of the immunological system would be achieved by using a morphine-Diazepam combination.