Antioxidant Activities of Some New Chromonyl-2,4-Thiazolidinediones and Chromonyl-2,4-Imidazolidinediones Having Chromone Cores

Berczynski P., Kladna A., Kruk I., Piechowska T., Aboul-Enein H. Y., BOZDAĞ DÜNDAR O., ...Daha Fazla

JOURNAL OF FLUORESCENCE, cilt.23, sa.6, ss.1319-1327, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s10895-013-1266-y
  • Dergi Adı: JOURNAL OF FLUORESCENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1319-1327
  • Anahtar Kelimeler: Chromonyl-2,4-thiazolidinediones, Chromonyl-2,4-imidazolidinediones, Radical scavenging activity, Chemiluminescence, Electron paramagnetic resonance, SUPEROXIDE, CHEMILUMINESCENCE, ANTIBIOTICS, FLAVONOIDS, CHEMISTRY, RADICALS
  • Ankara Üniversitesi Adresli: Evet

Özet

The antioxidant properties of 11 new synthesized chromonyl-2,4-thiazolidinediones and chromonyl-2,4-imidazolidinediones (CBs) were investigated. The antioxidant activities and mechanisms of the CBs interaction with reactive oxygen species (ROS) were clarified using various in vitro antioxidant assay methods including superoxide anion radical (), hydroxyl radical (HOaEuro cent), 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPHaEuro cent) scavenging activity and the iron (II)-ferrozine complex formation. The potassium superoxide/18-crown-6 ether dissolved in dimethylsulfoxide (DMSO) was applied as a source of superoxide anion radical. Hydroxyl radicals were produced in the Fenton-like reaction Fe(II)+H2O2. Chemiluminescence, spectrophotometry, and electron paramagnetic resonance (EPR) spectroscopy using 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) as spin trap were applied as the measurement techniques. The CBs examined that exhibited good free radical scavenging activity also showed strong total antioxidant power capacity. Possible mechanisms of antioxidation are proposed to explain the differences in the experimental results between the chromone derivatives with imidazolidine-2,4-dione ring and those with thiazolidine-2,4-dione ring. In conclusion, some of the new CBs are promising to be applied as inhibitors of free radicals.