Akademik Veri Yönetim Sistemi
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.33, sa.1, ss.27-40, 2004 (Scopus, TRDizin)
Cannabis resin is among the most used illegal Cannabis products over the world. Cannabis resin prepared usually as hard tablets or blocks and can be smoked by crumbling small amounts into a tobacco containing hand-rolled cigarette. The estrogenic activity of smoke of Cannabis resin has been tested in this study. The estrogenic activity in smoke samples has been detected by using the Recombinant Yeast Assay, which is the most widely used in-vitro test method to detect the estrogen-like activity in new chemicals. As well known estrogenic active chemicals have been suspected of contributing to a range of adverse health effects in humans, including reproductive and developmental disorders, learning problems, and immune system dysfunction. Several recent trends in human health may be related to endocrine disruptors in the environment: widespread occurrence of neurobehavioral dysfunction at birth and in childhood; an increasing incidence of testicular cancer in young men; an increasing incidence of congenital malformations of the male reproductive tract; the increasing incidence of breast cancer; and declining sperm counts. Because of the above mentioned adverse health problems, the presence of the estrogenic active chemicals in the smoke of Cannabis resin should also be taken into consideration as an additional health risk for the users of Cannabis products. Consequently, the estrogenic activity of smoke samples was statistically higher (p<0.05) than the negative control (DMSO) and 03 nM 17_estradiol according to our results.