Akademik Veri Yönetim Sistemi
ANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRY, cilt.19, sa.3, ss.314-322, 2018 (SCI-Expanded, Scopus, TRDizin)
Objective: This study was aimed to analyze the serum total antioxidant/total oxidant (TAS/TOS) levels and thiol/disulphide balance of children with autism spectrum disorders (ASD) and draws a comparison with those of healthy children. Methods: The study involved 46 children diagnosed with ASD, along with 45 healthy children. The developmental stage, degree of intelligence and autism symptom severity of the ASD group were assessed using the Autism Behavior Checklist (ABC), Problematic Behavior Control List (PBCL), Childhood Autism Checklist Scale (CARS) and developmentally appropriate screening or IQ tests. Clinical, sociological and demographic data were obtained for both groups. The TAS/TOS levels and thiol/disulphide balance of both groups were analyzed and their oxidative stress index was obtained from the formula TAS/TOSx100. SPSS 17.0 was used for statistical analyses. p<0.05 was accepted to be statistically significant. Results: While lower TAS, native thiol and total thiol levels were found in the ASD group, other indices such as TOS, OSI and serum thiol-disulphide were similar for both groups. Discussion: Although no measurable effect upon the severity of autism was noted, the total antioxidant and thiol levels may be a significant cause of oxidative imbalance in ASD and our findings may suggest a predictive usefulness for TAS/TOS and thiol/disulphide balance, suggesting that treatments for ASD that take advantage of the potential advantages of antioxidants should be developed.