Investigating the potential use of (ZnO)60 nanoparticle as drug delivery system for chloroquine, hydroxychloroquine, favipiravir, and remdesivir

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Kurban M., Muz I.

MATERIALS TODAY COMMUNICATIONS, vol.38, pp.108488, 2024 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 38
  • Publication Date: 2024
  • Doi Number: 10.1016/j.mtcomm.2024.108488
  • Journal Name: MATERIALS TODAY COMMUNICATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Compendex, INSPEC
  • Page Numbers: pp.108488
  • Ankara University Affiliated: Yes

Abstract

This study delves into the potential use of (ZnO)60 nanoparticle (NP) as a drug delivery system for chloroquine (CQ), hydroxychloroquine (HC), favipiravir (F), and remdesivir (R). The interaction mechanisms between (ZnO)60 NP and these drug molecules are explored using advanced computational methods. A comprehensive evaluation of the structural, electronic, and reactivity properties of the drug molecules during their interaction with (ZnO)60 NP is conducted. The findings reveal that (ZnO)60 NP exhibit stable and favorable interactions with CQ, HC, F, and R, positioning them as promising candidates for targeted drug delivery. This research significantly contributes to the development of improved therapeutic interventions and provides valuable insights into the field of drug delivery systems.