A rapid lateral flow stool antigen immunoassay and C-14-urea breath test for the diagnosis and eradication of Helicobacter pylori infection in children

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Atıf İçin Kopyala

KULOĞLU Z., KANSU TANCA A., TUNA KIRSAÇLIOĞLU C., Uestuendag G., Aysev D., ENSARİ A., ...Daha Fazla

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, cilt.62, sa.4, ss.351-356, 2008 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 62 Sayı: 4
• Basım Tarihi: 2008
• Doi Numarası: 10.1016/j.diagmicrobio.2008.07.006
• Dergi Adı: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.351-356
• Anahtar Kelimeler: Children, Helicobacter pylori, Immunoassay, Immunochromatography, Stool antigen test, C-14 urea breath test, MONOCLONAL ENZYME-IMMUNOASSAY, C-14 UREA, ACCURACY, VALIDATION, GASTRITIS, AGE
• Ankara Üniversitesi Adresli: Evet

Özet

Our aim was to evaluate diagnostic accuracy of rapid immunochromatographic stool antigen test (Rapid HpSA; LINEAR Chemical, Barcelona, Spain) and a practical low-dose C-14 urea breath test (UBT) (Heliprobe(TM)) test before and after eradication therapy. One hundred nine children with abdominal symptoms (age range, 5-17 years; mean, 12.1) underwent endoscopy, C-14-UBT, and Rapid HpSA. Patients were defined as Hp infected when histology was positive for Hp. Forty children (36.6%) were Hp infected. The sensitivity of Rapid HpSA and C-14-UBT was 65% and 92.5% (P = 0.0003), respectively; the specificity of Rapid HpSA and C-14-UBT was 92.3% and 85.5% (P = 0.180), respectively. After eradication therapy endoscopy, C-14-UBT and Rapid HpSA were repeated. The eradication rate was 70.5%. After eradication, the sensitivity of Rapid HpSA and C-14-UBT was 60% and 100%, respectively; the specificity of Rapid HpSA and C-14-UBT was 100%. C-14-UBT was more reliable than the Rapid HpSA test for the diagnosis and for confirming eradication of Hp infection. (C) 2008 Elsevier Inc. All rights reserved.