Does the platelet-activating factor affect the antioxidant defense system? The possible role of hyperbaric oxygenation

Yildirim G., BAŞTUĞ M., Akcil I., FIÇICILAR H., Koc E., Zaloglu N.

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.78, sa.1-3, ss.7-12, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 78 Sayı: 1-3
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1385/bter:78:1-3:7
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.7-12
  • Anahtar Kelimeler: platelet-activating factor, hyperbaric oxygenation, intracellular antioxidant enzymes, trace elements, reactive oxygen species, SUPEROXIDE-DISMUTASE, RESPONSES, WEB-2086, ENZYMES, INJURY, ZINC
  • Ankara Üniversitesi Adresli: Evet

Özet

The platelet-activating factor (PAF) is an inflammatory mediator and it may exert some of its effects by reactive oxygen species (ROS). We investigated the effects of PAF and hyperbaric oxygenation (HBO) on copper (Cu) and zinc (Zn) levels in plasma and the intracellular antioxidant enzyme activities of rats. PAF administiration caused a decrease in erythrocyte catalase (CAT) and glutathione peroxidase (GPx) activities and in the plasma zinc level. Following PAF administration, exposure to HBO also caused a decrease in erythrocyte GPx activity. These results support the hypothesis that PAF may produce free oxygen radicals and HBO enhances this effect, The enzyme activities of the antioxidant defense system were found to be affected by these oxidative processes. This is likely to be the result of excessive production of ROS or overutilization and/or inhibition of the antioxidant enzymes.