Impact of colonic mucosal lipoxin A(4) synthesis capacity on healing in rats with dextran sodium sulfate-induced colitis

Agis E. R., SAVAŞ B., MELLİ M.

PROSTAGLANDINS & OTHER LIPID MEDIATORS, cilt.121, ss.63-69, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 121
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.prostaglandins.2015.04.001
  • Dergi Adı: PROSTAGLANDINS & OTHER LIPID MEDIATORS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.63-69
  • Anahtar Kelimeler: Ulcerative colitis, Inflammatory resolution, Misoprostol, 5-Aminosalicylic acid, Lipoxin A(4), Dextran sodium sulfate induced-colitis, INFLAMMATORY-BOWEL-DISEASE, ACID-INDUCED COLITIS, MISOPROSTOL, RESOLUTION, CYCLOOXYGENASE-2, EXACERBATION, INHIBITION, MEDIATORS, DRUGS
  • Ankara Üniversitesi Adresli: Evet

Özet

Ulcerative colitis is a chronic inflammatory disease of the colon. This study evaluates the role of colonic mucosal lipoxin A(4) (LXA(4)) synthesis in an experimental rat model of dextran sodium sulfate (DSS)-induced colitis. Wistar rats were randomly assigned to four groups: healthy controls, DSS-induced colitis with no or vehicle therapy, misoprostol or 5-aminosalicylic acid (5-ASA) therapy groups. Disease severity and colonic mucosal LXA(4) synthesis was assessed specifically during the acute phase (day 5), chronic phase (day 15) and healing phases (day 19).