Chemoresistance in Malignant Intracranial Tumors: Longer Survival with Negative MDR1 Expression

Ezgu M. C., Kural C., Simsek G. G., Kaygin P., OĞUZTÜZÜN S., Kirik A., ...More

TURKISH NEUROSURGERY, vol.31, no.3, pp.447-459, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.5137/1019-5149.jtn.29819-20.3
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.447-459
  • Keywords: Brain, Tumor, Glutathione S-transferase, Cytochrome p450, Multidrug resistance, GLUTATHIONE S-TRANSFERASES, GENETIC POLYMORPHISMS, GENOTYPES, RISK, MRP1
  • Ankara University Affiliated: Yes

Abstract

AIM: To analyze the Glutathione S-transferase (GST)-P, GST-M, cytochrome p450 (CYP)1-A1, CYP1-B1, and multidrug resistance (MDR)-1 expressions in malignant intracranial tumor (ICT)s, and to elicit their role on patient survival.