Fertility preservation in female patients
HUMAN REPRODUCTION UPDATE, vol.10, no.3, pp.251-266, 2004 (SCI-Expanded, Scopus)
- Publication Type: Article / Review
- Volume: 10 Issue: 3
- Publication Date: 2004
- Doi Number: 10.1093/humupd/dmh021
- Journal Name: HUMAN REPRODUCTION UPDATE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.251-266
- Keywords: chemotherapy, fertility preservation, ovarian failure, radiotherapy, BONE-MARROW-TRANSPLANTATION, LONG-TERM SURVIVORS, IN-VITRO FERTILIZATION, TOTAL-BODY IRRADIATION, INTRACYTOPLASMIC SPERM INJECTION, FOLLICLE-STIMULATING-HORMONE, OVARIAN CORTICAL STRIPS, HUMAN OOCYTE CRYOPRESERVATION, SYSTEMIC-LUPUS-ERYTHEMATOSUS, ACUTE LYMPHOBLASTIC-LEUKEMIA
- Open Archive Collection: AVESIS Open Access Collection
- Ankara University Affiliated: Yes
Abstract
In the USA alone, >650000 women will be afflicted by cancer in 2003, and 8% of these cases will be aged <40 years. Due to improvements in cancer therapy, cure rates of both adult and childhood cancers increased significantly over the past three decades. However, long-term consequences of cancer therapy and impact on quality of life are now being recognized. One of the major sequelae of cytotoxic chemotherapy is gonadal failure. Cytotoxic chemotherapy and/or radiotherapy are not only used to treat malignant diseases, but also non-malignant systemic conditions. Upon reviewing the extent and mechanism of gonadal damage due to chemo-/radiotherapy, this article discusses indications and the wide range of methods of fertility preservation in a comprehensive manner. All current, emerging, experimental as well as controversial approaches are reviewed. A comprehensive algorithm to manage fertility preservation through an individualized approach is presented.