Synthesis and antidiabetic activity of some new chromonyl-2,4-thiazolidinediones

Ceylan-Unlusoy M., Verspohl E. J., Ertan R.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.25, sa.6, ss.784-789, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 6
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3109/14756360903357544
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.784-789
  • Anahtar Kelimeler: Chromone, 2,4-thiazolidinediones, chromonyl-2,4-thiazolidinediones, antidiabetic activity, synthesis, AGENTS
  • Ankara Üniversitesi Adresli: Evet

Özet

A series of chromonyl-2,4-thiazolidinediones/imidazolidinediones/2-thioxo-imidazolidine-4-ones (IIIa-i, IVa-i) was prepared by Knoevenagel reaction of 2,4-thiazolidinedione/2,4-imidazolidinedione/2-thioxo-imidazolidine-4- one (IIa-c) with 2/3-formyl chromone (Ia-b) and then alkylation with methyl/ethyl iodide. The prepared compounds were tested for their insulinotropic activities in INS-1 cells. Compounds iVb and iVc (at lower concentration, 1 mu g/mL) were able to increase insulin release in the presence of 5.6 mmol/L glucose." should be written as "Compounds IVb and IVc (at lower concentration, 1 mu g/mL) and also IIId and IIIg (at higher concentration) were able to increase insulin release in the presence of 5.6 mmol/L glucose. Compounds iVb and iVc (at lower concentration, 1 mu g/mL) were able to increase insulin release in the presence of 5.6 mmol/L glucose.