Follicular fluid norepinephrine and dopamine concentrations are higher in polycystic ovary syndrome

Musali N., ÖZMEN B., ŞÜKÜR Y. E., ERGÜDER B. İ., ATABEKOĞLU C. S., SÖNMEZER M., ...Daha Fazla

GYNECOLOGICAL ENDOCRINOLOGY, cilt.32, sa.6, ss.460-463, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/09513590.2015.1130808
  • Dergi Adı: GYNECOLOGICAL ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.460-463
  • Anahtar Kelimeler: Catecholamine, dopamine, in vitro fertilization, norepinephrine, polycystic ovary syndrome, OXIDATIVE STRESS, ANTIOXIDANTS, GENERATION, METABOLISM, PHYSIOLOGY, IMPACT
  • Ankara Üniversitesi Adresli: Evet

Özet

The aim of the present study was to compare follicular fluid (FF) levels of norepinephrine (NE) and dopamine (DA) in polycystic ovary syndrome (PCOS) and non-PCOS patients who underwent in vitro fertilization (IVF). Forty-seven PCOS patients (study group) and 61 patients with male factor infertility (control group) who underwent IVF using GnRH agonist protocol were recruited. Concentrations of NE and DA were measured in FF specimens of all patients. Demographic characteristics were comparable between the groups. Significantly higher levels of NE were measured in FF of PCOS patients (median: 61.05 nmol/l) compared to those with male infertility (median: 49.82 nmol/l). Similarly, significantly higher levels of DA were measured in FF of PCOS patients (median: 23.70 nmol/l) compared to those with male infertility (median: 18.28 nmol/l). In conclusion, the FF concentrations of both catecholamine are increased in PCOS patients when compared to non-PCOS patients.