New voltammetric approach to the quantitative estimation of sildenafil citrate in tablets using disposable pencil graphite electrode

Güzel R., Ekşi H., DİNÇ E., Solak A. O.

Sensor Letters, cilt.12, sa.11, ss.1675-1681, 2014 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 11
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1166/sl.2014.3384
  • Dergi Adı: Sensor Letters
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Biotechnology Research Abstracts, Communication Abstracts, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1675-1681
  • Anahtar Kelimeler: Differential pulse stripping voltammetric determination, Experimental design and optimization, Pencil graphite electrode, Plasma samples, Sildenafil citrate
  • Ankara Üniversitesi Adresli: Evet

Özet

Copyright © 2014 American Scientific PublishersThe voltammetric behavior of sildenafil citrate (SC) was studied through differential pulse stripping voltammetry. The best sensitivity, optimal experimental conditions and settings for the voltammetric method development were obtained by applying experimental design and optimization methodology to the designed sample runs at different accumulation times, accumulation potentials and pHs. The linearity over the concentration range 1 × 10-7 M-8 × 10-6 M for SC was determined and the limit of detection (LOD) was 3.1 × 10-8 M. For the method ability and validity, mean recovery result and relative standard deviation were found to be 99.3% and 2.19%, respectively. The method was applied to the determination of SC in pharmaceutical and plasma samples.