Analysis of moisture content in hard gelatin capsules at different stability conditions

Canefe K., BOZKIR A., Badri S.

Acta Pharmaceutica Turcica, vol.38, no.1, pp.1-4, 1996 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 1
  • Publication Date: 1996
  • Journal Name: Acta Pharmaceutica Turcica
  • Journal Indexes: Scopus, International Pharmaceutical Abstracts
  • Page Numbers: pp.1-4
  • Keywords: gelatin capsule, isotherm, moisture transfer, relative humidity
  • Ankara University Affiliated: Yes

Abstract

The moisture adsorption properties of the capsule dosage forms which were produced in our laboratory have been investigated in this study at different temperature and moisture conditions. For this purpose three active substances (caffeine, procaine hydrochloride and ammonium chloride), showing distinct physical reactions to temperature and humidity, have been selected and moisture adsorption was observed on empty capsules. We also analyzed by the equations of adsorption and the data well fitted the B.E.T. equation for empty capsules. However the use of adsorption equations forfilled capsules indicated that no significant results were obtained for their moisture adsorption features.