Effects of Carbontetrachloride (CCl4) on some Blood Values in Pregnant and Non-pregnant Rats

Sert N. N., ALTINSAAT Ç.

KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, vol.14, no.2, pp.237-242, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2008
  • Doi Number: 10.9775/kvfd.2008.69-a
  • Journal Name: KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.237-242
  • Keywords: Carbontetrachloride, Rat, Blood values, Pregnancy, CARBON-TETRACHLORIDE, LIPID-PEROXIDATION, LIVER, INTOXICATION, ETHANOLAMINE, PROTECTION, DAMAGE
  • Ankara University Affiliated: Yes

Abstract

In this investigation, the effect of CCl4 on some biochemical values in pregnant and non-pregnant rats was aimed to study. Twelve female 6-8 months old Wistar Albino rats weighing 150-250 g were used. Rats were divided randomly into two groups containing six in each. In one group pregnancy was achived by housing six female rats with a fertile male for one night. Blood was withdrawn from ether anesthetized rats through heart puncture, on the seventh day of pregnancy and non-pregnant rats for some biochemical measurements. Acute intoxication was induced in rats by injection a single dose of a mixture of CCl4 + olive oil (1:1), 2 ml/kg, intraperitonally. Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Lactate dehydrogenase (LDH) enzyme activities were increased significantly in pregnant and non-pregnant rats after CCl4 treatment. These results indicate the hepatic damage caused by acute toxic effects of carbon tetrachloride both in pregnant and non-pregnant rats.