Osteogenesis Imperfecta, Pseudoachalasia, and Gastric Cancer
CASE REPORTS IN GASTROINTESTINAL MEDICINE, cilt.2015, 2015 (ESCI)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2015
- Basım Tarihi: 2015
- Doi Numarası: 10.1155/2015/685459
- Dergi Adı: CASE REPORTS IN GASTROINTESTINAL MEDICINE
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
- Ankara Üniversitesi Adresli: Evet
Özet
Osteogenesis imperfecta (OI) is a rare, inherited skeletal disorder characterized by abnormalities of type 1 collagen. Malignancy is rarely reported in patients with OI and it was suggested that this disease can protect against cancer. Here, we report a 41-year-old woman with symptoms of achalasia where repeated treatment of pneumatic dilation and stent replacement was unsuccessful; therefore, surgery was performed. Pathology showed gastric adenocarcinoma unexpectedly. Chemotherapy was given after assessing dihydropyrimidine dehydrogenase (DPD) enzyme activity, which can be deficient in OI patients. This is the first report of gastric cancer mimicking achalasia in a patient with OI.