A tri-serine tri-lactone scaffold for the quantification of citrate in urine

Akdeniz A., ÇAĞLAYAN M. G., Anzenbacher P.

CHEMICAL COMMUNICATIONS, cilt.52, sa.9, ss.1827-1830, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 9
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1039/c5cc08759g
  • Dergi Adı: CHEMICAL COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1827-1830
  • Ankara Üniversitesi Adresli: Evet

Özet

Tri-serine tri-lactone based C-3 symmetry fluorescent sensors were synthesized. Citrate is shown to bind to sensors, while displaying an increase in fluorescence intensity for the sensor with thiourea and a quenching for the sensor with sulfonamide. Information-rich responses of the sensors enable us to discriminate structurally similar anions, including mono-, di- and tri-carboxylates with 100% correct classification. A simple two-sensor array enables the determination of the concentration of citrate in urine without any sample preparation with high accuracy (error < 2%).