Akademik Veri Yönetim Sistemi
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY, sa.3, ss.216-221, 2007 (ESCI)
Purpose: To evaluate the clinical features, property of treatment and prognosis in patients with orbital melanoma. Material and Methods: Between June 1996 and January 2006, seventeen eyes of the seventeen patients with orbital melanoma were evaluated retrospectively at the Department of Ophthalmology, Ankara University Faculty of Medicine. Following incisionel/excisionel biopsy of the orbital melanoma, external beam radiotherapy was administered in the presence of positive surgical margins in histopathologic examination and chemotherapy was given in the presence of systemic metastasis. Results: There were ten males and seven females. The mean age at diagnosis was 55.9 years (range; 33 to 71 years). Diagnosis of the primary tumor was choroid melanoma in eight patients, conjunctival melanoma in four patients, conjunctiyal-caruncul melanoma in two patients, ciliary body melanoma in two patient and conjunctival and eyelid melanoma in one patient. Fourteen patients had orbital involvement at the time of diagnosis; three patients developed orbital involvement subsequently at a mean period of 43.3 months (range; 17-67 months). We performed orbital exenteration in eleven patients (total exenteration in seven patients, eyelid-sparing exenteration in four patients), enucleation in four patients and orbitotomy in one patient. We didn't apply any surgical treatment in one patient because of the presence of distant metastases. External beam radiotherapy was used in nine patients. Additionally chemotherapy was used in five because of the presence of systemic metastasis. The mean follow-up time after orbital involvement was 24.6 months (range: 7-83 months). The mean follow-up time after initial diagnosis was 40.8 months (range: 12-83 months). At the end of the follow-up, 14 patients were alive with disease, three patient died of metastatic disease. Discussion: Orbital melanoma usually develops from orbital extension of uveal and conjunctival melanomas. Orbital involvement is a risk factor for systemic metastasis. Combinations of surgical treatment, external beam radiotherapy and chemotherapy were used in these patients.