EFFECTS OF TIMOLOL TREATMENT ON PANCREATIC ANTIOXIDANT ENZYMES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS: AN EXPERIMENTAL AND COMPUTATIONAL STUDY

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Ulusu N. N., GÖK M., Erman B., Turan B.

JOURNAL OF MEDICAL BIOCHEMISTRY, cilt.38, sa.3, ss.306-316, 2019 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2478/jomb-2018-0034
  • Dergi Adı: JOURNAL OF MEDICAL BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.306-316
  • Anahtar Kelimeler: glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, cAMP, diabetes, timolol, SOLUBLE ADENYLYL-CYCLASE, OXIDATIVE STRESS, GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY, INSULIN-RESISTANCE, BETA-BLOCKER, ACTIVATION, CONTRIBUTES, INHIBITION, PROTECTS, PENTOSE
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: The study aimed to investigate whether timolol-treatment has a beneficial effect on pentose phosphate pathway enzyme activities such as glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGDH) enzyme activities and cAMP level in streptozotocin-induced diabetic rats in pancreatic tissues