EFFECTS OF TIMOLOL TREATMENT ON PANCREATIC ANTIOXIDANT ENZYMES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS: AN EXPERIMENTAL AND COMPUTATIONAL STUDY

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Ulusu N. N., GÖK M., Erman B., Turan B.

JOURNAL OF MEDICAL BIOCHEMISTRY, vol.38, no.3, pp.306-316, 2019 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.2478/jomb-2018-0034
  • Journal Name: JOURNAL OF MEDICAL BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.306-316
  • Keywords: glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, cAMP, diabetes, timolol, SOLUBLE ADENYLYL-CYCLASE, OXIDATIVE STRESS, GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY, INSULIN-RESISTANCE, BETA-BLOCKER, ACTIVATION, CONTRIBUTES, INHIBITION, PROTECTS, PENTOSE
  • Ankara University Affiliated: Yes

Abstract

Background: The study aimed to investigate whether timolol-treatment has a beneficial effect on pentose phosphate pathway enzyme activities such as glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGDH) enzyme activities and cAMP level in streptozotocin-induced diabetic rats in pancreatic tissues