Akademik Veri Yönetim Sistemi
SLOVENIAN VETERINARY RESEARCH, cilt.62, ss.41-53, 2025 (SCI-Expanded)
Canine hemangiosarcoma is an aggressive cancer with a poor prognosis. It originates in the cells that line blood vessels and affects various organs, including the spleen, heart, and liver. Despite its rarity, canine hemangiosarcoma presents significant diagnostic and therapeutic challenges. Certain breeds, such as Golden Retrievers, Boxers, and German Shepherds, have a higher susceptibility to Hemangiosarcoma (HSA), suggesting a possible genetic basis for disease susceptibility. However, the exact molecular mechanisms underlying the predisposition of these breeds to HSA are not fully understood. This study aimed to improve our understanding of the molecular mechanisms underlying canine hemangiosarcoma by re-analyzing publicly available RNA sequencing data using bioinformatic techniques in dogs. Our results suggest that the genes ALB, TNNT2, VIM and CA9 have the potential to be used as novel biomarkers for spleen, heart, and liver HSA in the Golden Retriever breed. Based on our findings, we propose that STAT3, TP53, PPARG,ATF3, CCND1, and miR-21-5p, miR-92a-3p, and miR155-5p have the potential to serve as biomarkers for hepatic HSA in Golden Retrievers. In addition, our analysis of splenic HSA datasets from six different dog breeds reveals the expression of breed-specific genes in canine splenic HSA. The identification of these biomarkers enhances our understanding of the molecular mechanisms involved in AS and provides potential targets for therapeutic intervention.