Akademik Veri Yönetim Sistemi
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, cilt.14, sa.1, ss.1-7, 2008 (SCI-Expanded)
This study was performed for investigating the effects of oxybutynin and tolterodine on in vitro circulary and longitudinal smooth muscle of rabbit bladder. In this research, ten male New Zeland rabbits weight 4-5 kg were used. One circulary and longitudinal strips were prepared taken from the isolated bladder. At first, 1 g of strecth was applied to tissues adapt to media. Next, fallowing adapt time, the electrical Stimulation level which created submaximal contraction was determined and this stimulation was performed by adding different concentrations of oxybutynin, tolterodine and atropine respectively. Firstly 10(-7)M dosage of oxybutynin (10(-7)M, 10(-6)M, 10(-5)M) was added and waited for 15 minutes. At the end of this period, electrical stimulation was applied to get the contraction response of the tissue. After stimulation, tissue. was washed once for every two minute twice and rested, tissue was waited until its starting stretch value. Same processes were performed for oxybutynin (10(-6)W, 10(-5)M), tolterodine (10(-8)M, 10(-7)M, 10(-6)M) and atropines' (10(-7)M, 10(-6)M, 10(-5)M) other dosages. As a result, it was opbserved that oxybutynin and tolterodine due to their increasing concentrations prevented the contractions at circulary and longitudinal smooth muscle of rabbit bladder by electrical stimulation. It was determined that contractions at circulary muscle were prevented more strongly by oxybutynin and contractions at longitudinal muscle were prevented more strongly by tolterodine.