Voltammetric oxidation of ambroxol and application to its determination in pharmaceuticals and in drug dissolution studies

Demircigil B., Uslu B., Ozkan Y., Ozkan S. A., Senturk Z.

Electroanalysis, cilt.15, sa.3, ss.230-234, 2003 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1002/elan.200390029
  • Dergi Adı: Electroanalysis
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.230-234
  • Anahtar Kelimeler: ambroxol, cyclic voltammetry, differential pulse voltammetry, glassy carbon electrode, formulation analysis, dissolution profile, LIQUID-CHROMATOGRAPHIC DETERMINATION, HUMAN-PLASMA, QUANTIFICATION, HYDROCHLORIDE, BROMHEXINE, FLUIDS, URINE, ASSAY
  • Ankara Üniversitesi Adresli: Evet

Özet

A detailed study of the electrochemistry of ambroxol at a glassy carbon electrode was carried out in the pH range 1.8-11.0 in aqueous solution using cyclic and differential pulse voltammetry. The compound was oxidized irreversibly at high positive potentials resulting in the formation of a chemical product at less positive potentials, which was more readily oxidized than the parent compound. In addition, a differential pulse voltammetric method was proposed for the determination of the drug in different pharmaceutical formulations, and in drug dissolution studies.