Voltammetric oxidation of ambroxol and application to its determination in pharmaceuticals and in drug dissolution studies
Electroanalysis, cilt.15, sa.3, ss.230-234, 2003 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 3
- Basım Tarihi: 2003
- Doi Numarası: 10.1002/elan.200390029
- Dergi Adı: Electroanalysis
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.230-234
- Anahtar Kelimeler: ambroxol, cyclic voltammetry, differential pulse voltammetry, glassy carbon electrode, formulation analysis, dissolution profile, LIQUID-CHROMATOGRAPHIC DETERMINATION, HUMAN-PLASMA, QUANTIFICATION, HYDROCHLORIDE, BROMHEXINE, FLUIDS, URINE, ASSAY
- Ankara Üniversitesi Adresli: Evet
Özet
A detailed study of the electrochemistry of ambroxol at a glassy carbon electrode was carried out in the pH range 1.8-11.0 in aqueous solution using cyclic and differential pulse voltammetry. The compound was oxidized irreversibly at high positive potentials resulting in the formation of a chemical product at less positive potentials, which was more readily oxidized than the parent compound. In addition, a differential pulse voltammetric method was proposed for the determination of the drug in different pharmaceutical formulations, and in drug dissolution studies.