Strategies to manage retinoblastoma in developing countries

Chantada G. L., Qaddoumi I., Canturk S., Khetan V., Ma Z., Kimani K., ...Daha Fazla

Pediatric Blood and Cancer, cilt.56, sa.3, ss.341-348, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 56 Sayı: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1002/pbc.22843
  • Dergi Adı: Pediatric Blood and Cancer
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.341-348
  • Anahtar Kelimeler: Compliance, Developing countries, Late diagnosis, Retinoblastoma
  • Ankara Üniversitesi Adresli: Evet

Özet

Survival of retinoblastoma is >90% in developed countries but there are significant differences with developing countries in stage at presentation, available treatment options, family compliance, and survival. In low-income countries (LICs), children present with advanced disease, and the reasons are socioeconomic and cultural. In middle-income countries (MICs), survival rates are better (>70%), but there is a high prevalence of microscopically disseminated extraocular disease. Programs for eye preservation have been developed, but toxicity-related mortality is higher. Although effective treatment of microscopically extraocular disease improved the outcome, worldwide survival will be increased only by earlier diagnosis and better treatment adherence. © 2010 Wiley-Liss, Inc.