Iloprost maintains acetylcholine relaxations of isolated rabbit aortic strips submitted to hypoxia

TURKER R., DEMIREL E.

Pharmacology, cilt.36, sa.3, ss.151-155, 1988 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 3
  • Basım Tarihi: 1988
  • Doi Numarası: 10.1159/000138378
  • Dergi Adı: Pharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.151-155
  • Anahtar Kelimeler: Endothelium-dependent relaxation, Hypoxia, Iloprost, Protection, Rabbit aorta
  • Ankara Üniversitesi Adresli: Evet

Özet

The protective activity of iloprost against hypoxia was studied in isolated rabbit aortic strips precontracted with angiotensin II on the relaxant effect of acetylcholine. Exposure of the strips to hypoxia in the medium of Krebs alone for 48 h caused a highly significant decrease in the relaxing effect of acetylcholine without altering that of papaverine. Iloprost (10-9 mol/1), when added to the incubation medium before hypoxia, prevented the loss of the relaxing effect of acetylcholine in angiotensin II preconctracted strips. These results were taken as evidence indicating possible protective activity of iloprost in vascular endothelium. © 1988 S. Karger AG, Basel.