Protective role of antioxidant vitamins on adriamycin-induced free radical production and cardiotoxicity in guinea pigs

Durak I., ÖZTÜRK H. S., Kavutcu M., Birey M., Yel M., Guven T., ...Daha Fazla

CANCER RESEARCH THERAPY & CONTROL, cilt.5, sa.2, ss.133-141, 1998 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 2
  • Basım Tarihi: 1998
  • Dergi Adı: CANCER RESEARCH THERAPY & CONTROL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.133-141
  • Anahtar Kelimeler: adriamycin, cardiotoxicity, vitamins E and C, LIPID-PEROXIDATION, HEART MICROSOMES, INDUCED CARDIOMYOPATHY, HYDROGEN-PEROXIDE, CARDIAC TOXICITY, ANTHRACYCLINE, DOXORUBICIN, INHIBITION, ICRF-187, SUPEROXIDE
  • Ankara Üniversitesi Adresli: Evet

Özet

Guinea pigs were divided into three groups: control, adriamycin and adriamycin plus vitamin groups, and treated with physiological saline solution (control group), adriamycin (adriamycin group) and adriamycin plus vitamins E and C (adriamycin plus vitamin group). Activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) and concentrations of malondialdehyde (MDA), conjugated dienes (CD), hydroxyl radical (OH.) and iron were measured in heart and liver tissues of all animals. Electron microscopic analysis and free radical concentrations of all tissues were also carried out.