The Inflammation Network in the Pathogenesis of Erectile Dysfunction: Attractive Potential Therapeutic Targets

KAYA SEZGİNER E., GÜR S.

CURRENT PHARMACEUTICAL DESIGN, vol.26, no.32, pp.3955-3972, 2020 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 26 Issue: 32
  • Publication Date: 2020
  • Doi Number: 10.2174/1381612826666200424161018
  • Journal Name: CURRENT PHARMACEUTICAL DESIGN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.3955-3972
  • Keywords: Erectile dysfunction, endothelial dysfunction, metabolic disease, inflammation, cytokines, anti-inflammatory drugs, NITRIC-OXIDE SYNTHASE, NECROSIS-FACTOR-ALPHA, ENDOTHELIUM-DEPENDENT VASODILATATION, CARDIOVASCULAR RISK-FACTORS, RENIN-ANGIOTENSIN SYSTEM, CORONARY-ARTERY-DISEASE, CAVERNOUS NERVE INJURY, C-REACTIVE PROTEIN, TNF-ALPHA, METABOLIC SYNDROME
  • Ankara University Affiliated: Yes

Abstract

Background: Erectile dysfunction (ED) is an evolving health problem in the aging male population. Chronic low-grade inflammation is a critical component of ED pathogenesis and a probable intermediate stage of endothelial dysfunction, especially in metabolic diseases, with the inclusion of obesity, metabolic syndrome. and diabetes.