Antioxidant status in cerebrovascular accident

Kocaturk P., AKBOSTANCI M. C., Isikay C., Ocal A., Tuncel D., Kavas G., ...Daha Fazla

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.80, sa.2, ss.115-124, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 80 Sayı: 2
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1385/bter:80:2:115
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.115-124
  • Anahtar Kelimeler: cerebrovascular accident, superoxide dismutase, catalase, zinc, copper, SUPEROXIDE-DISMUTASE, FREE-RADICALS, BRAIN-INJURY, MECHANISMS, ISCHEMIA
  • Ankara Üniversitesi Adresli: Evet

Özet

Ischemia is associated with the pathological changes caused by the accumulation of reactive oxygen metabolites (ROM) in cerebrovascular accident (CVA). The aim of this study was to determine red cell copper/zinc-superoxide dismutase (Cu/Zn-SOD) and catalase activities and copper and zinc concentrations both in plasma and in red cells in CVA. Cu/Zn-SOD and catalase activities of 16 patients, with an average age of 64 yr, were measured spectrophotometrically; copper and zinc concentrations were determined by atomic absorption spectrophotometer. The results showed that Cu/Zn-SOD activity was increased markedly in patients compared to the young controls and reached a peak on the d 5 of the disease, whereas the catalase activity of the patients on d 3 and d 5 were in the normal range, but higher on d 10. The enzyme activities of the elderly group were generally increased compared to the young controls. Copper and zinc concentrations showed corresponding alterations. These findings suggested that the effects of oxidative stress in CVA might be reflected in red cell and plasma parameters.